Pumpkin Seeds: 11 Evidence-Based Health Benefits

By Sayer Ji

Pumpkin seeds, like all edible seeds, pack an immense nutritional and medicinal punch. After all, they contain future worlds within their compact structure. 

In order to prepare their “babies” for survival outside the pumpkin, nature equips seeds with an extremely dense source of organically bound nutrients, including exceptionally high levels of health-promoting minerals.

Pumpkin Seeds Nutritional Virtues

For example, a one cup serving (64 grams) of pumpkin seeds has 44 percent daily value (DV) of zinc, 22 percent of copper, 42 percent magnesium, 16 percent manganese, 17 percent potassium, and enough iron (17 percent DV) to improve iron-deficiency associated anemia. And remember, food-derived minerals are far more bioavailable and biocompatible than inorganic forms.

But beyond the obvious nutritional virtues of the seed, recent scientific investigations have revealed that pumpkin seed meal, as well as its pressed oil, may have great therapeutic value in alleviating the following conditions:

Prostate Growth: pumpkin seed has been studied for its ability to inhibit testosterone-induced prostate growth, a common causative factor in benign prostatic hyperplasia.^{1, 2} It was also proven safe and effective in a 2014 clinical trial comparing it to the drug Prozasin.

Postmenopausal Symptoms: Women supplemented with 2,000 mg of pumpkin seed oil over the course of 12 weeks were found to have reduced blood pressure, increased HDL cholesterol, as well as reduction in the severity of hormone insufficiency associated symptoms (eg, hot flash, headaches and join pain).³ Additional experimental research indicates that adverse cardiovascular changes associated with estrogen deficiency, such as blood pressure and lipid abnormalities, can be mitigated with pumpkin seed oil.⁴

Calcium-Oxalate Kidney Stones: According to a study performed in 1987 and published in the American Journal of Clinical Nutrition, children with calcium-oxalate crystals in their urine responded favorably to the supplementation of their diet with pumpkin seeds.⁵

Cardiovascular and Liver Disease: A mixture of flaxseed and pumpkin seed was found to have heart-protective and liver-protective properties in an animal study from 2008 published in the Journal of Food Chemistry & Toxicology.⁶

Drug & Chemical Toxicity: The protein isolate of pumpkin seed has been shown to alleviate acetaminophen (Tylenol) toxicity on the liver,⁷ and as methotrexate-induced small intestine damage in an animal model.⁸ It has also been studied to protect against carbon tetrachloride-induced liver injury.⁹

Arthritis: Pumpkin seed oil was found to compare favorably with the NSAID drug indomethacin in an experimental model of arthritis, but without causing liver damage, in a study published in 1995 in the Journal of Pharmacological Research.¹⁰

Hypertension: Animals fed pumpkin seed oil were found to respond more favorably to conventional drug-treatment with Ace-inhibitors and Calcium Channel Blockers, likely because of its beneficial antioxidant properties.¹¹

Parasites: A preclinical canine study has shown that pumpkin seeds have significant activity against canine intestinal parasites.¹²

Insomnia/Anxiety: Pumpkin seeds contain a high level of tryptophan (22mg/gram of pumpkin seed protein)—the amino acid precursor to serotonin, which is itself converted to melatonin, the “sleep hormone,” in the evening. Research published in 2007 in the Canadian Journal of Physiology and Pharmacology found that when de-oiled pumpkin seed was taken in combination with glucose, a clinical effect similar to that of pharmaceutical-grade tryptophan was achieved.¹³ A 2005 study published in the journal Nutritional Neuroscience found that pumpkin seed sourced tryptophan in combination with carbohydrate was as effective as pharmaceutical tryptophan in reducing awake time during the night.

Androgenic Alopecia (ie, male pattern baldness): A 2014 randomized, double-blind, placebo-controlled trial published in Evidence Based Complementary Alternative Medicine found that men receiving pumpkin seed oil saw 30 to 40 percent increased hair counts while the placebo group showed only 5 to 10 percent more hair count on average. 

Overactive Bladder/Urinary Disorders: A 2014 clinical trial found that pumpkin seed oil, at 10 grams per day for 12 weeks, was safe and effective in reducing Overactive Bladder Symptom Score (OABSS) in patients with overactive bladder.

These, of course, are only some of the experimentally confirmed beneficial properties of pumpkin seed. Like all foods, there are likely countless properties that—within the right context, the right timing, and the right amount—fulfill Hippocrates’ age-old and timeless proclamation that food can be our medicine.

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This article was adapted by Well Being Journal from the previously published original article at greenmedinfo.com titled “Pumpkin Seeds: 11 Evidence-Based Health Benefits,” published August 30th, 2019.

References

1. “Pumpkin Seed Oil and Phytosterol-F can Block Testosterone/prazosin-induced Prostate Growth in Rats.” Urol Int. 2006;77(3):269-74. PMID: 17033217
2. “Inhibition of Testosterone-induced Hyperplasia of the Prostate of Sprague-dawley Rats by Pumpkin Seed Oil.” QJM. 2008 Mar;101(3):167-79. Epub 2008 Jan 25. PMID: 16822218
3. “Improvement in HDL Cholesterol in Postmenopausal Women Supplemented with Pumpkin Seed Oil: Pilot Study.” Climacteric. 2011 May 5. Epub 2011 May 5. PMID: 21545273
4. “Supplementation with Pumpkin Seed Oil Improves Plasma Lipid Profile and Cardiovascular Outcomes of Female Non-ovariectomized and Ovariectomized Sprague-Dawley Rats.” Phytother Res. 2008 Jul;22(7):873-7. PMID: 18567058
5. “The Effect of Pumpkin Seeds on Oxalcrystalluria and Urinary Compositions of Children in Hyperendemic Area.” Am J Clin Nutr. 1987 Jan;45(1):115-21. PMID: 3799495
6. “Hypolipidemic and Hepatoprotective Effects of Flax and Pumpkin Seed Mixture Rich in Omega-3 and Omega-6 Fatty Acids in Hypercholesterolemic Rats.” Food Chem Toxicol. 2008 Dec;46(12):3714-20. Epub 2008 Oct 1. PMID: 18938206
7. “In Vitro Antioxidative Activity of Pumpkin Seed (Cucurbita pepo) Protein Isolate and Its In Vivo Effect on Alanine Transaminase and Aspartate Transaminase in Acetaminophen-induced Liver Injury in Low Protein Fed Rats.” Phytother Res. 2006 Sep ;20(9):780-3. PMID: 16807884
8. “Protective Effect of Ellagic Acid and Pumpkin Seed Oil Against Methotrexate-induced Small Intestine Damage in Rats.” Indian J Biochem Biophys. 2011 Dec ;48(6):380-7. PMID: 22329239
9. “Effect of Pumpkin Seed (Cucurbita pepo) Protein Isolate on the Activity Levels of Certain Plasma Enzymes in CCl4-induced Liver Injury in Low-protein Fed Rats.” Phytother Res. 2005 Apr ;19(4):341-5. PMID: 16041732
10. “Effect of Pumpkin-seed Oil on the Level of Free Radical Scavengers Induced During Adjuvant-arthritis in Rats.” Pharmacol Res. 1995 Jan;31(1):73-9. PMID: 7784309
11. “Pumpkin-seed Oil Modulates the Effect of Felodipine and Captopril in Spontaneously Hypertensive Rats.” Pharmacol Res. 2000 May;41(5):555-63. PMID: 10753555
12. “Preclinical Studies of Cucurbita maxima (Pumpkin Seeds) a Traditional Intestinal Antiparasitic in Rural Urban Areas.” Rev Gastroenterol Peru. 2004 Oct-Dec;24(4):323-7. PMID: 15614300
13. “Protein-source Tryptophan as an Efficacious Treatment for Social Anxiety Disorder: a Pilot Study.” Can J Physiol Pharmacol. 2007 Sep;85(9):928-32. PMID: 18066139