Coffee Boosts Longevity while Fighting Cancer

By GreenMedInfo Research Group

Coffee, one of the world’s most popular beverages, is a panacea of potential health benefits. Loaded with antioxidants, it has been shown to imbue anti-inflammatory properties and disease protection when consumed in moderation.¹ But you don’t have to stop at just one cup. Thanks to a recent study, coffee’s known benefits have been given a ringing endorsement—benefits that may increase with each cup you drink.

Researchers at Dana-Farber Cancer Institute published a large observational study² nested within a clinical trial of novel drug treatments for patients with colorectal cancer. The study, published in the journal JAMA Oncology, analyzed dietary patterns and long-term health outcomes for a cohort of patients who had completed phase 3 of the randomized clinical trial sponsored by the National Cancer Institute.

Coffee Gets a Boost from Science

Data were collected from more than 1,500 patients being treated for advanced or metastatic colorectal cancer. Dietary intake and lifestyle questionnaires were obtained during and post-treatment, then correlated and analyzed for patterns over time.

Specific analysis of coffee intake was included, with participants being excluded from the caffeine cohort for aberrant caloric intake (<600 or >4200 kcal for men; <500 or >3500 kcal for women) and if cancer had worsened or death had occurred within 90 days of enrollment. Final data analysis was performed on information from 1,171 patients.

The study results provide a real boost for coffee drinkers. Patients who reported drinking two to three cups a day were likely to live longer overall and had a longer time before their disease worsened compared to those who didn’t drink it. In good news for the caffeine-sensitive, the anticancer benefits were observed in both caffeinated and decaffeinated drinkers.

These results confirmed the findings of prior studies on coffee’s effects on cancer³ and add scientific weight to it’s growing reputation as a disease-fighting superfood. But can more of a good thing be too much?

Another Cup? Just Say, “Yes”

Despite such promising research findings, many believe that drinking multiple cups of coffee each day can lead to ill health. For individuals with caffeine sensitivities, moderation should be exercised. That being said, for the colorectal cancer patients enrolled in this study, the benefits increased the more they consumed.

The impressive life-extending and cancer-delaying benefits were observed at two to three cups daily, however the greatest measure of benefit was observed in patients who consumed four or more cups each day.⁴

Researchers posit that these benefits may be related to coffee’s ability to decrease blood insulin levels by sensitizing tissues to the effects of insulin, or to coffee’s antioxidant, anti-inflammatory, and antiangiogenic (tumor-inhibiting) effects.⁵

Coffee’s Impressive Anticancer Effects

While this study highlights the association between daily consumption and improved outcomes in patients with metastatic colorectal cancer, the authors point out that association does not equal causation, and further study is needed to determine if there is a causal relationship.

According to senior author, Kimmie Ng, “Although it is premature to recommend a high intake of coffee as a potential treatment for colorectal cancer, our study suggests that drinking it is not harmful and may potentially be beneficial.”⁶

In metastatic forms of cancer, cancer cells break away from the original tumor site and migrate, via the blood or lymphatic system, to form new tumors in other parts of the body.⁷ Since coffee’s anticancer effects have been demonstrated on a variety of different cancers, including colorectal, liver, breast, head, and neck cancers,⁸ its potential as an anticancer treatment is attracting attention from researchers.

A meta-analysis examining coffee consumption and colorectal cancer risk detected a significant protective effect from it in seven US studies.⁹ But the health benefits don’t stop there; it may offer a veil of protection for both body and mind.

Disease Prevention and Longer Life

Coffee consumption was the focus of a meta-analysis of the PubMed and Web of Science research databases through March 2019 reviewing 40 studies involving nearly 4 million individuals. Researchers found that intakes of around 3.5 cups per day lowered the risk of all-cause mortality, results that were irrespective of age, weight, alcohol consumption, smoking status, and caffeine content of the coffee.¹⁰

Another impressive benefit involves its ability to stabilize the body’s insulin response. In a meta-analysis published in the American Diabetes Association’s Diabetes Care journal, which included 28 studies involving more than 1.1 million people, coffee consumption was shown to be inversely associated with the risk of Type 2 diabetes, another effect that was dose-dependent and applied to both caffeinated and decaffeinated types.¹¹

Good for Energy and Mood

While the energy-boosting effects of coffee are legendary, did you know that it can also improve your mood?

A 2011 study showed that coffee can stimulate the release of dopamine, the neurotransmitter associated with enhanced mood effects, in the brain.¹²

Don’t like the taste?

Not to worry—there are other ways to infuse your body with coffee’s mood-enhancing properties. In a randomized clinical trial published in the peer-reviewed journal, Advances in Mind Body Medicine, patients seeking mood support for moderate depression were administered coffee enemas as part of a detoxification strategy aimed at enhancing mood and reducing protracted withdrawal symptoms from psychotropic medication tapering.

At the end of the 44-day lifestyle-modification program, patients reported a 50 percent reduction in symptoms, with coffee enemas being credited for alleviating acute withdrawal symptoms by helping to synthesize glutathione, a potent antioxidant that plays a critical role in cellular detoxification functions.¹³ 

Does it help you get through the day?

If so, you may be poised to live a longer, healthier life thanks to these truly wonderful beans. To learn more about the holistic benefits of coffee, explore the scientific abstracts on GreenMedInfo.com.

References

1. Mackintosh C, Yuan C, Ou F, et al. “Association of Coffee Intake with Survival in Patients with Advanced or Metastatic Colorectal Cancer.” JAMA Oncol. 2020;6(11):1713-1721. doi: 10.1001/jamaoncol.2020.3938
2. ibid.
3. Dana-Farber Cancer Institute. “Coffee associated with improved survival in metastatic colorectal cancer patients.” ScienceDaily, 17 September 2020. www.sciencedaily.com/releases/2020/09/200917181251.htm.
4. ibid.
5. Mackintosh C, op cit. 
6. Dana-Farber Cancer Institute, op cit.
7. Cancer.gov, Types, Metastatic Cancer, https://www.cancer.gov/types/metastatic-cancer
8. Susan M Gapstur, Rebecca L Anderson, Peter T Campbell, Eric J Jacobs, Terryl J Hartman, Janet S Hildebrand, Ying Wang, Marjorie L McCullough. “Associations of Coffee Drinking and Cancer Mortality in the Cancer Prevention Study-II.” Cancer Epidemiol Biomarkers Prev. 2017 Jul 27. Epub 2017 Jul 27. PMID: 28751477
9. ibid.
10. Youngyo Kim, Youjin Je, Edward Giovannucci. “Coffee Consumption and All-Cause and Cause-specific Mortality: a Meta-analysis by Potential Modifiers.” Eur J Epidemiol. 2019 May 4. Epub 2019 May 4. PMID: 31055709
11. Ming Ding, Shilpa N. Bhupathiraju, Mu Chen, Rob M. van Dam, Frank B. Hu “Caffeinated and Decaffeinated Coffee Consumption and Risk of Type 2 Diabetes: A Systematic Review and a Dose-Response Meta-analysis.” Diabetes Care. Feb 2014, 37 (2) 569-586; DOI: 10.2337/dc13-1203
12. J Walker, B Rohm, R Lang, M W Pariza, T Hofmann, V Somoza. “Identification of Coffee Components that Stimulate Dopamine Release from Pheochromocytoma Cells (PC-12).” Food Chem Toxicol. 2011 Oct 13. Epub 2011 Oct 13. PMID: 22019894
13. KellyBroganMd.com, “Psychotropic Drug Withdrawal and Holistic Tapering Strategies: A Case Series.” https://kellybroganmd.com/wpcontent/uploads/2016/02/PsychotropicDrugWithdrawal.pdf
14. This article is copyrighted by GreenMedInfo LLC, 2021, originally posted on 12 January 2021 at https://www.greenmedinfo.com/blog/coffee-boosts-survival-colorectal-cancer-patients
15. The GMI Research Group (GMIRG) is dedicated to investigating the most important health and environmental issues of the day. Special emphasis will be placed on environmental health. Our focused and deep research will explore the many ways in which the present condition of the human body directly reflects the true state of the ambient environment.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

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